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APS
Announces Recipients of the 2006 Future Leaders in Pain Research
Small Grants
The 2006 Future
Leaders in Pain Research Small Grants Program offered funding for
five researchers, in the amount of $20,000. To be eligible, grant
applicants must be APS members who are within 6 years of completion
of their terminal degree and have not yet been awarded major NIH
or foundation grant funding. There were twenty competitive applications
for funding this year. Members of the APS Small Grants Committee
reviewed and scored the applications in preparation for selection
of grant recipients.
APS is proud
to announce the following 2006 grant recipients. Each of the recipients
will attend the Annual Scientific Meeting to report on the progress
of their research studies to the members of the Small Grants Committee.
Marie Hoeger
Bement, PT PhD
Marquette University
Milwaukee, WI
“Acute Hormonal Fluctuations as a Mechanism for Exercise-Induced
Hypoalgesia in Women”
Beth D. Darnall,
PhD
Oregon Health & Science University
Portland, OR
“A Prospective Investigation of Immunologic Response to Negative
Cognition in Persons with Chronic Pain”
Jill C. Fehrenbacher,
PhD
University of Texas Health Science Center–San Antonio
San Antonio, TX
“Sex-Dependent Modulation of Clinical Outcomes Following Laparoscopic
Cholecystectomy”
Bryan C. Hains,
PhD
Yale University
West Haven, CT
“Supraspinal Modulation of Pain after SCI by Microglia”
Theodore J.
Price, PhD
McGill University
Montreal, Canada
“Role of RNA Transport and Local Translation in Nociceptive
Processing”
APS gratefully
acknowledges Endo Pharmaceuticals and Cephalon for their generous
funding of the 2006 grants program and extends special thanks to
the members of the Grants Committee for their efforts on behalf
of the program.
APS
Small Grants Committee
Sandra Ward, PhD RN, Chair
Michael Caterina, PhD
C. Richard Chapman, PhD
James Eisenach, MD
Roger Fillingim, PhD
Gerald F. Gebhart, PhD
Jennifer Haythornthwaite, PhD
Keela Herr, PhD RN
Charles Inturrisi, PhD
Robert Jamison, PhD
Mitchell Max, MD
Kathleen Sluka, PhD
George Wilcox, PhD
The 2007 grant application information will become
available in May. Applications will be due in July.
Pain
Bill Reintroduction Expected in 2007
While the new
Congress busies itself with leadership initiatives and snaring prize
committee assignments, the Pain Care Coalition (PCC) is working
on a new legislative strategy to secure passage of a comprehensive
pain care legislation that has failed in the previous two Congresses.
The PCC includes APS, the American Academy of Pain Medicine, the
American Headache Society, and the American Society of Anesthesiology.
Democrats are
now the majority in the House and Senate, and the first priorities,
according to PCC legislative counsel Robert Saner, are to determine
if the Republican lead sponsor of the previous pain bills, Rep.
Mike Rogers of Michigan, is still interested in pushing pain legislation,
and to recruit majority party lead sponsors in the House and Senate.
”It’s really not possible to engage members right now,”
said Saner, “so our focus is on identifying Democrats who
might step forward on behalf of pain care and continue our collaboration
with Congressman Rogers.”
Saner further
noted that PCC didn’t come away from the last Congress empty
handed, even though the Pain Care Policy Act of 2005 never made
it through the House Energy and Commerce Committee. “While
it was frustrating we weren’t more successful in moving the
Rogers bill, language from it was included in the NIH reform legislation,”
he said. “Specifically, chronic pain is now recognized as
a disease category that needs to be tracked. I see this as a significant
achievement that could pay off in the future in requiring NIH to
track pain research funding and report to Congress every year on
what the Institutes are spending on chronic pain.”
In 2007, PCC
will change its legislative strategy and support two separate but
different pain bills. One will focus on the military and veterans,
and will be considered by the Veterans and Armed Services committees
and subcommittees in the House and Senate. The other would be a
less aggressive version of the previous Rogers bills that would
focus on empowering the Pain Care Consortium within NIH and contain
other HHS-related provisions similar to the Rogers bill.
“During
deliberations on the NIH reform bill, we saw there is strong bipartisan
consensus against creating new units at NIH,” said Saner.
“Even though Democrats traditionally are partial to healthcare
legislation, it’s clear that proposals to establish regional
pain centers and other units within NIH wouldn’t get much
support on either side of the aisle. Our approach now is to pursue
an appropriations strategy to get seed money for the Pain Care Consortium
to become a more effective advocate for pain care and pain research.”
Sponsoring a
pain bill for the military and veterans involves different committees
and offers opportunities to recruit new cosponsors and supporters
in the House and Senate. Saner added that satisfying pain care needs
of soldiers wounded in Iraq and Afghanistan could generate considerable
support for the legislation.
Saner hopes
that one or both pain bills will be introduced by April. “That
means the timing of the Capitol Hill visits scheduled during the
APS Annual Meeting in May will be beneficial for educating House
and Senate members about increasing federal funding for pain care
and pain research.”
Register
Now!
APS 26th Scientific Meeting
May
2–5, 2007
Washington Convention Center
Washington, DC
The APS 26th
Annual Scientific Meeting will be a lively arena for interdisciplinary
exchange among pain scientists and healthcare professionals. In
the ever-expanding field of pain management, new trends, techniques,
therapies, and diagnostic procedures become available almost daily.
Knowledge of these is crucial for the practicing healthcare professional
when selecting the most efficacious treatment for the individual
patient. By attending and participating in the meeting, you will
be able to relate clinical insights presented to questions of basic
science, and to translate scientific innovations to your clinical
practice.
Online registration is open. Register
today!

NIH
Pain Consortium 2nd Annual Symposium
Advances in Pain Research
May
1, 2007
Masur Auditorium
NIH Clinical Center
Bethesda, MD
The NIH Pain
Consortium will hold its second annual symposium, Advances in Pain
Research, immediately before the APS Annual Scientific Meeting.
Panel sessions
will be presented by NIH researchers and will highlight advances
in inflammatory, neuropathic, treatment-induced, and visceral pain.
Poster sessions will be presented by NIH-supported investigators.
The meeting is open to the public.
This meeting
is sponsored by the NIH. For additional information, please contact
Linda Porter, PhD, NINDS, at 301/496-9964.
SIG
Programs
Each year the
APS Special Interest Groups plan a variety of education sessions
and business meetings for members. The following sessions are scheduled
to take place during the annual meeting.
Thursday,
May 3
Basic
Science
The Basic Science SIG will meet to discuss various topics of interest.
The Basic Science liaisons to the APS Board of Directors and the
Scientific Program Committee will give brief reports of progress
and activities over the year. There will also be open discussion
from the floor and the nomination and election of a new co-chair
for 2007–2008. The content of the 2008 Basic Science Research
Forum Dinner Symposium will be addressed, and a brief data blitz
from three early career scholars will conclude the meeting. Speakers
for the meeting will include Drs. Lucy Vulchanova, Derek Molliver,
and Greg Dussor.
Genetics
and Pain
This meeting will involve an informative presentation concerning
some of the newer genetic methodologies available for the study
of pain. After the presentation, the group will discuss goals for
the coming year, collaborative research opportunities, educational
opportunities, and other agenda items. Dr. William Lariviere will
give a talk on QTL Mapping and Covariance Analyses of Pain Traits,
Nonpain Traits, and Transcript Levels Using the Recombinant Inbred
Mouse Model.
Interdisciplinary
Pain Rehabilitation
In 2005, the Interdisciplinary Pain Rehabilitation SIG was formed
because despite overwhelming evidence that comprehensive interdisciplinary
treatment for chronic pain is both clinically and fiscally efficacious,
third-party payers remain reluctant to pay for it and therefore
many of the pain programs that opened in the 1980s have closed.
This year the SIG is hosting a symposium on the survival of interdisciplinary
treatment of chronic pain. Additionally, we plan to develop a list
and descriptions of all national interdisciplinary pain programs
to be shared with APS member and the public. The results of a patient
satisfaction survey done by the American Chronic Pain Association
will be reviewed.
Measurement
in Pain and Its Impact, Part I
There are many developments in all areas of pain research and clinical
practice related to measurement of pain. Some areas have seen bigger
and some smaller advances, but all constitute progress. This meeting
will review current status and development in a few major areas.
One theme that will be articulated is that recent technological
and conceptual advances add to our ability to measure and assess
pain, including electronic pain scales, better methods of conducting
quantitative sensory testing, and pain assessment instruments for
different pain conditions (e.g., neuropathic pain scales). This
will be discussed further during this session, and other areas will
be explored during the second meeting on Saturday.
Nursing
Issues
The Nursing Issues SIG will present “Challenging Aspects of
Evidence-Based Pain Management Nursing.”
Pain
in Infants, Children, and Adolescents
The annual SIG business meeting will be held.
Psychosocial
Research
A data blitz will be conducted in which researchers will briefly
present new data on psychosocial pain research.
Friday, May 4
Clinical
Trials
This dynamic program will include five lectures on several emerging
clinical trials issues related to pain. The tentative topics include
general considerations in combination analgesic treatment, handling
of missing data, responders analyses, FDA perspective on regulatory
issues involving analgesics, and gastrointestinal function during
moderate-to-severe pain. Speakers include Peter Lacouture, John
Farrar, Raymond Dionne, Gus Larijani, and Bob Rappaport.
Disparity
in Pain Management
The first half of the meeting will be devoted to the discussion
of a number of topics. The SIG will confirm the slate of newly elected
officers, and SIG activities at the APS meeting and from the past
year will be reviewed. Plans for the upcoming year then will be
previewed, including plans that are relevant to the 2008 APS meeting.
The second half of the meeting will be devoted to a data blitz,
in which attendees will present recently collected data in a telescoped
fashion (no more than three minutes per presentation with another
two minutes for discussion with group). The presentations and order
of presentations will be determined prior to the APS meeting.
Ethics
The Ethics SIG is in the process of planning its meeting.
Palliative
Care
The Palliative Care SIG is in the process of planning its meeting.
Pharmacotherapy
This inaugural meeting will begin with a 20-minute presentation
by the SIG Chair, David Craig, PharmD BCPS, followed by a discussion
of the future activities of the SIG, annual elections, and planning
for the first SIG-sponsored symposia in 2008.
Saturday, May 5
Measurement
of Pain and Its Impact, Part II
There are many developments in all areas of pain research and clinical
practice related to measurement of pain. Some areas have seen bigger
and some smaller advances, but all constitute progress. This meeting
will review current status and development in a few major areas.
In this particular session, which is a continuation of our discussion
from our first SIG meeting on Thursday, May 3, we will explore the
question of measuring individual differences in pain sensitivity,
a problem of enormous significance for conducting successful clinical
trials and pain research studies.
Balanced
Pain Policy Initiative
The American
Pain Society was invited to be part of the Balanced Pain Policy
Initiative, which is led by the Center for Practical Bioethics and
includes the National Association of Attorneys General, the Federation
of State Medical Boards, American Academy of Pain Medicine (AAPM),
American Pain Foundation, Pain and Policy Studies Group, Drug Enforcement
Administration, and others, and was formed to promote balanced public
policy. The group is developing a research project to ensure that
all people with pain have access to the most appropriate medications
and to prevent controlled substances from being diverted for illicit
purposes. As members of this group, APS and AAPM recently conducted
a qualitative survey on prescribing practices and attitudes. Over
470 physician members from the two organizations participated. These
results will be shared with the work group at its next meeting on
January 17. Watch for more information in next month’s APS
E-News.
News
Highlights from The Journal of Pain
The
following highlights summarize selected articles from the December
2006 issue (volume 8, number 1).
Sex
and Pain-Related Psychological Variables are Associated with Thermal
Pain Sensitivity for Patients with Chronic Low Back Pain
Steven Z. George, Virgil T. Wittmer, Roger B. Fillingim, and
Michael E. Robinson
University of Florida
There have been
many published studies comparing and evaluating thermal pain sensitivity
in healthy subjects, but not much research has been conducted on
those with clinical pain syndromes. The authors studied 33 patients
with low back pain to explore whether sex differences existed for
thermal pain sensitivity and if sex, fear avoidance beliefs, and/or
pain catastrophizing influenced thermal-pain sensitivity. This is
known as the Fear-Avoidance Model of Exaggerated Pain Perception
(FAMEPP).
The authors
hypothesized that women with chronic low back pain would exhibit
elevated pain sensitivity in response to evoked pain stimuli and
that fear-avoidance beliefs and catastrophizing would significantly
influence pain sensitivity for all subjects regardless of gender.
The authors defined fear avoidance beliefs as comprising an individual’s
pain experiences, present stress level, pain behavior, and personality
traits. Catastrophizing was described as a general negative expectation
that experienced pain will inevitably result in the worst possible
outcome.
Based on self-report
questionnaires of the study subjects, the authors concluded that
sex differences were evident in this group because women showed
lower pain tolerance. However, the survey results also indicated
that fear avoidance beliefs were the only unique influence on first-pulse
response to pain stimuli in both women and men. Therefore, fear
avoidance was associated with immediate thermal-pain sensitivity.
Is High Fear of Pain Associated with Attentional
Biases for
Pain-Related or General Threat?
Gordon J. G. Asmundson and Heather D. Hadjistravropoulos
University of Regina, Canada
The intent of
this study was to review and clarify past mixed research findings
related to establishing fear of pain as a critical variable stimulating
hypervigilance and vulnerability to the disabling effects of pain.
A previous study had found that fear of pain was associated with
faster detection of weak electrical stimuli regardless of clinical
status.
The researchers
reviewed recently published dot-probe data from 36 patients with
musculoskeletal pain and from 29 healthy subjects. They concluded
that patients with high pain fear levels displayed hypervigilance
for all word types presented during the dot-probe task compared
to those with low fear levels. The high pain fear subjects were
almost exclusively musculoskeletal pain patients.
It appears from
the data that high pain fear is associated with a general hypervigilance
for potentially threatening stimuli. Fear of pain, therefore, can
be used to categorize people more or less vulnerable to the disabling
effects of pain, as those with high fear are likely to selectively
react to all potentially threatening stimuli in their environment.
Musculoskeletal Pain in Primary Health
Care: Subgroups Based on Pain Intensity, Disablity, Self Efficacy,
and Fear Avoidance Variables
Eva Denison, Pernilla Asenlof, Maria Sandborgh, and Per Lindberg
Department of Public Health and Caring Sciences, Uppsala University,
Sweden
Persistent pain
is commonly treated in the primary care setting and musculoskeletal
pain is the most frequently reported type of pain. The purpose of
this study was to identify and describe subgroup profiles of these
patients based on self-reported pain intensity, disability, self
efficacy, fear of movement, and catastrophizing.
The researchers
evaluated self-report questionnaires given to two groups of 215
and 161 patients at the start of physical therapy. Three subgroups
were identified in the first group and replicated in the second.
They were labeled as “high self-efficacy and low fear avoidance,”
“low self-efficacy and low fear avoidance” and “low
self-efficacy and high fear avoidance.”
The authors
stated that the high self-efficacy and low fear avoidance group
was the largest subgroup in both samples, and therapeutic management
of these patients could be based on a general fitness approach in
which they would be expected to self-manage extensively. For those
with a combination of high pain levels and disability and low self-efficacy,
the authors recommended a treatment approach that would enhance
self-efficacy beliefs regarding the performance of desired activities
by focusing on mastery of required motor skills. For the third subgroup,
characterized by high pain levels and disability and high fear avoidance,
they advocated an approach that assesses what movements or activities
elicit fear and to follow up with gradual activity increases to
reduce catastrophizing and fear and to enhance self-efficacy.
Travel
Support for the APS 26th Annual Scientific Meeting
APS will again
offer Young Investigator Awards for travel to the 2007 meeting.
Awards are available to individuals presenting paper or poster abstracts
at the meeting, May 2–5, 2007, in Washington, DC. Applicants
may be from any research training background (basic or clinical
science, psychology, medicine, or biostatistics) and may be at any
level in training, including students, residents, predoctoral trainees,
postdoctoral fellows, or those who have completed their postdoctoral
training within the last 3 years. All applicants must be members
of APS.
Please consult
with your institution to verify that you can accept a cash award
from APS before submitting an application for Young Investigator
funding. Some institutions have policies that only allow for in-kind
contributions, and APS will distribute cash awards to those chosen
to receive Young Investigator awards.
To apply for
funding, complete the Young
Investigator Travel Stipend Application
located on the APS Web site (beginning January 15, 2007).
Applications must be completed online by February 19, 2007. If you
have difficulty completing the application, contact Jennifer Reinard
at jreinard@connect2amc.com
or 847/375-4833. Applications will be reviewed by the APS Scientific
Program Planning Committee and stipends will be awarded by March
12, 2007. Notifications will be sent to all applicants after March
12. All eligible young investigators will receive their travel grants
at the Annual Meeting.
The APS travel
stipend program is made possible through external grants as well
as an allocation of operating funds from the American Pain Society.
Centers
of Excellence: Deadline Is Almost Here!

APS
created the Centers of Excellence (COE) in Pain Management Awards
Program to help advance the quality of pain management in the United
States by recognizing and rewarding excellence in quality clinical
care. Any multidisciplinary program that provides direct patient
care and is primarily focused on the treatment of pain is eligible
to apply. Applications will be accepted through January 19, 2007,
and award recipients will be announced by the end of the first quarter
of 2007. Applications must be submitted online.
Country
Profiles on Opioid Availability Now Available
The Pain &
Policy Studies Group (PPSG) recently announced enhancements to the
international section of its Web site that may be useful for individuals
and organizations interested in improving availability and access
to essential opioid medications. The PPSG Web
site now offers country profiles that provide standardized information
about opioid availability and key policy-related indicators for
every country in the world. Each country profile contains graphs
that portray the trend in reported national consumption of principal
opioids as an indicator of opioid availability. Key policy-related
indicators are provided, including whether the country is a party
to the international conventions that require governments to estimate
their medical requirements for opioids and to report consumption
statistics to the International Narcotics Control Board. Country
profiles can be accessed directly at www.painpolicy.wisc.edu/internat/countryprofiles.htm
or from
the PPSG home page.
APS
Bulletin Online
Past issues of the APS Bulletin are archived online for
your convenience and reference. This month, we’re highlighting
three articles that perhaps you may have missed when they were first
published.
Overcoming
Legal Barriers to Competent and Compassionate Pain Relief for Patients
with Chronic Nonmalignant Pain
Ben Rich, MD JD
(Volume 15, Number 4, Fall 2005)
Veterans
Health Administration National Pain Management Strategy: Update
and Future Directions
Robert D. Kerns, John Booss, Martha Bryan, Michael E. Clark,
Audrey C. Drake, Rollin M. Gallagher, Beverly Green-Rashad, Ruth
Markham, Jack Rosenberg, Anne Turner
(Volume 16, Number 1, Winter 2006)
Practical
Controlled Trials: Researching the Therapeutic Ritual and All Its
Parts
David Rakel, MD
(Volume 16, Number 3, Fall 2006)
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