E-News Archive Index

APS E-News
January 2007

Allen Lebovits, PhD, Editor

Reminders

Centers of Excellence: Applications due January 19

Young Investigator Travel Support: Applications
due February 19

APS Election Ballots Are Coming Soon!

In This Issue

APS Announces Recipients of the 2006 Future Leaders in Pain Research Small Grants

Pain Bill Reintroduction Expected in 2007

Register Now!
APS 26th Scientific Meeting

NIH Pain Consortium 2nd Annual Symposium

SIG Programs

Balanced Pain Policy Initiative

News Highlights from The Journal of Pain

Travel Support for the APS 26th Annual Scientific Meeting

Centers of Excellence: Deadline Is Almost Here!

Country Profiles on Opioid Availability Now Available

APS Bulletin Online

 

Acknowledgment:
APS E-News is made possible through an unrestricted educational grant from Purdue Pharma, L.P.

American Pain Society
4700 W. Lake Avenue
Glenview, IL 60025-1485
847/375-4715
Fax: 877/734-8758

info@ampainsoc.org

 

 

 

 

 

 

 

 

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APS Announces Recipients of the 2006 Future Leaders in Pain Research Small Grants

The 2006 Future Leaders in Pain Research Small Grants Program offered funding for five researchers, in the amount of $20,000. To be eligible, grant applicants must be APS members who are within 6 years of completion of their terminal degree and have not yet been awarded major NIH or foundation grant funding. There were twenty competitive applications for funding this year. Members of the APS Small Grants Committee reviewed and scored the applications in preparation for selection of grant recipients.

APS is proud to announce the following 2006 grant recipients. Each of the recipients will attend the Annual Scientific Meeting to report on the progress of their research studies to the members of the Small Grants Committee.

Marie Hoeger Bement, PT PhD
Marquette University
Milwaukee, WI
“Acute Hormonal Fluctuations as a Mechanism for Exercise-Induced Hypoalgesia in Women”

Beth D. Darnall, PhD
Oregon Health & Science University
Portland, OR
“A Prospective Investigation of Immunologic Response to Negative Cognition in Persons with Chronic Pain”

Jill C. Fehrenbacher, PhD
University of Texas Health Science Center–San Antonio
San Antonio, TX
“Sex-Dependent Modulation of Clinical Outcomes Following Laparoscopic Cholecystectomy”

Bryan C. Hains, PhD
Yale University
West Haven, CT
“Supraspinal Modulation of Pain after SCI by Microglia”

Theodore J. Price, PhD
McGill University
Montreal, Canada
“Role of RNA Transport and Local Translation in Nociceptive Processing”

APS gratefully acknowledges Endo Pharmaceuticals and Cephalon for their generous funding of the 2006 grants program and extends special thanks to the members of the Grants Committee for their efforts on behalf of the program.

APS Small Grants Committee
Sandra Ward, PhD RN, Chair
Michael Caterina, PhD
C. Richard Chapman, PhD
James Eisenach, MD
Roger Fillingim, PhD
Gerald F. Gebhart, PhD
Jennifer Haythornthwaite, PhD
Keela Herr, PhD RN
Charles Inturrisi, PhD
Robert Jamison, PhD
Mitchell Max, MD
Kathleen Sluka, PhD
George Wilcox, PhD

The 2007 grant application information will become available in May. Applications will be due in July.

 

Pain Bill Reintroduction Expected in 2007

While the new Congress busies itself with leadership initiatives and snaring prize committee assignments, the Pain Care Coalition (PCC) is working on a new legislative strategy to secure passage of a comprehensive pain care legislation that has failed in the previous two Congresses. The PCC includes APS, the American Academy of Pain Medicine, the American Headache Society, and the American Society of Anesthesiology.

Democrats are now the majority in the House and Senate, and the first priorities, according to PCC legislative counsel Robert Saner, are to determine if the Republican lead sponsor of the previous pain bills, Rep. Mike Rogers of Michigan, is still interested in pushing pain legislation, and to recruit majority party lead sponsors in the House and Senate. ”It’s really not possible to engage members right now,” said Saner, “so our focus is on identifying Democrats who might step forward on behalf of pain care and continue our collaboration with Congressman Rogers.”

Saner further noted that PCC didn’t come away from the last Congress empty handed, even though the Pain Care Policy Act of 2005 never made it through the House Energy and Commerce Committee. “While it was frustrating we weren’t more successful in moving the Rogers bill, language from it was included in the NIH reform legislation,” he said. “Specifically, chronic pain is now recognized as a disease category that needs to be tracked. I see this as a significant achievement that could pay off in the future in requiring NIH to track pain research funding and report to Congress every year on what the Institutes are spending on chronic pain.”

In 2007, PCC will change its legislative strategy and support two separate but different pain bills. One will focus on the military and veterans, and will be considered by the Veterans and Armed Services committees and subcommittees in the House and Senate. The other would be a less aggressive version of the previous Rogers bills that would focus on empowering the Pain Care Consortium within NIH and contain other HHS-related provisions similar to the Rogers bill.

“During deliberations on the NIH reform bill, we saw there is strong bipartisan consensus against creating new units at NIH,” said Saner. “Even though Democrats traditionally are partial to healthcare legislation, it’s clear that proposals to establish regional pain centers and other units within NIH wouldn’t get much support on either side of the aisle. Our approach now is to pursue an appropriations strategy to get seed money for the Pain Care Consortium to become a more effective advocate for pain care and pain research.”

Sponsoring a pain bill for the military and veterans involves different committees and offers opportunities to recruit new cosponsors and supporters in the House and Senate. Saner added that satisfying pain care needs of soldiers wounded in Iraq and Afghanistan could generate considerable support for the legislation.

Saner hopes that one or both pain bills will be introduced by April. “That means the timing of the Capitol Hill visits scheduled during the APS Annual Meeting in May will be beneficial for educating House and Senate members about increasing federal funding for pain care and pain research.”

Register Now!
APS 26th Scientific Meeting

May 2–5, 2007
Washington Convention Center
Washington, DC

 

The APS 26th Annual Scientific Meeting will be a lively arena for interdisciplinary exchange among pain scientists and healthcare professionals. In the ever-expanding field of pain management, new trends, techniques, therapies, and diagnostic procedures become available almost daily. Knowledge of these is crucial for the practicing healthcare professional when selecting the most efficacious treatment for the individual patient. By attending and participating in the meeting, you will be able to relate clinical insights presented to questions of basic science, and to translate scientific innovations to your clinical practice.

Online registration is open. Register today!

 

NIH Pain Consortium 2nd Annual Symposium
Advances in Pain Research

May 1, 2007
Masur Auditorium
NIH Clinical Center
Bethesda, MD

The NIH Pain Consortium will hold its second annual symposium, Advances in Pain Research, immediately before the APS Annual Scientific Meeting.

Panel sessions will be presented by NIH researchers and will highlight advances in inflammatory, neuropathic, treatment-induced, and visceral pain. Poster sessions will be presented by NIH-supported investigators. The meeting is open to the public.

This meeting is sponsored by the NIH. For additional information, please contact Linda Porter, PhD, NINDS, at 301/496-9964.

 

SIG Programs

Each year the APS Special Interest Groups plan a variety of education sessions and business meetings for members. The following sessions are scheduled to take place during the annual meeting.

Thursday, May 3

Basic Science
The Basic Science SIG will meet to discuss various topics of interest. The Basic Science liaisons to the APS Board of Directors and the Scientific Program Committee will give brief reports of progress and activities over the year. There will also be open discussion from the floor and the nomination and election of a new co-chair for 2007–2008. The content of the 2008 Basic Science Research Forum Dinner Symposium will be addressed, and a brief data blitz from three early career scholars will conclude the meeting. Speakers for the meeting will include Drs. Lucy Vulchanova, Derek Molliver, and Greg Dussor.

Genetics and Pain
This meeting will involve an informative presentation concerning some of the newer genetic methodologies available for the study of pain. After the presentation, the group will discuss goals for the coming year, collaborative research opportunities, educational opportunities, and other agenda items. Dr. William Lariviere will give a talk on QTL Mapping and Covariance Analyses of Pain Traits, Nonpain Traits, and Transcript Levels Using the Recombinant Inbred Mouse Model.

Interdisciplinary Pain Rehabilitation
In 2005, the Interdisciplinary Pain Rehabilitation SIG was formed because despite overwhelming evidence that comprehensive interdisciplinary treatment for chronic pain is both clinically and fiscally efficacious, third-party payers remain reluctant to pay for it and therefore many of the pain programs that opened in the 1980s have closed. This year the SIG is hosting a symposium on the survival of interdisciplinary treatment of chronic pain. Additionally, we plan to develop a list and descriptions of all national interdisciplinary pain programs to be shared with APS member and the public. The results of a patient satisfaction survey done by the American Chronic Pain Association will be reviewed.

Measurement in Pain and Its Impact, Part I
There are many developments in all areas of pain research and clinical practice related to measurement of pain. Some areas have seen bigger and some smaller advances, but all constitute progress. This meeting will review current status and development in a few major areas. One theme that will be articulated is that recent technological and conceptual advances add to our ability to measure and assess pain, including electronic pain scales, better methods of conducting quantitative sensory testing, and pain assessment instruments for different pain conditions (e.g., neuropathic pain scales). This will be discussed further during this session, and other areas will be explored during the second meeting on Saturday.

Nursing Issues
The Nursing Issues SIG will present “Challenging Aspects of Evidence-Based Pain Management Nursing.”

Pain in Infants, Children, and Adolescents
The annual SIG business meeting will be held.

Psychosocial Research
A data blitz will be conducted in which researchers will briefly present new data on psychosocial pain research.


Friday, May 4

Clinical Trials
This dynamic program will include five lectures on several emerging clinical trials issues related to pain. The tentative topics include general considerations in combination analgesic treatment, handling of missing data, responders analyses, FDA perspective on regulatory issues involving analgesics, and gastrointestinal function during moderate-to-severe pain. Speakers include Peter Lacouture, John Farrar, Raymond Dionne, Gus Larijani, and Bob Rappaport.

Disparity in Pain Management
The first half of the meeting will be devoted to the discussion of a number of topics. The SIG will confirm the slate of newly elected officers, and SIG activities at the APS meeting and from the past year will be reviewed. Plans for the upcoming year then will be previewed, including plans that are relevant to the 2008 APS meeting. The second half of the meeting will be devoted to a data blitz, in which attendees will present recently collected data in a telescoped fashion (no more than three minutes per presentation with another two minutes for discussion with group). The presentations and order of presentations will be determined prior to the APS meeting.

Ethics
The Ethics SIG is in the process of planning its meeting.

Palliative Care
The Palliative Care SIG is in the process of planning its meeting.

Pharmacotherapy
This inaugural meeting will begin with a 20-minute presentation by the SIG Chair, David Craig, PharmD BCPS, followed by a discussion of the future activities of the SIG, annual elections, and planning for the first SIG-sponsored symposia in 2008.


Saturday, May 5

Measurement of Pain and Its Impact, Part II
There are many developments in all areas of pain research and clinical practice related to measurement of pain. Some areas have seen bigger and some smaller advances, but all constitute progress. This meeting will review current status and development in a few major areas. In this particular session, which is a continuation of our discussion from our first SIG meeting on Thursday, May 3, we will explore the question of measuring individual differences in pain sensitivity, a problem of enormous significance for conducting successful clinical trials and pain research studies.

 

Balanced Pain Policy Initiative

The American Pain Society was invited to be part of the Balanced Pain Policy Initiative, which is led by the Center for Practical Bioethics and includes the National Association of Attorneys General, the Federation of State Medical Boards, American Academy of Pain Medicine (AAPM), American Pain Foundation, Pain and Policy Studies Group, Drug Enforcement Administration, and others, and was formed to promote balanced public policy. The group is developing a research project to ensure that all people with pain have access to the most appropriate medications and to prevent controlled substances from being diverted for illicit purposes. As members of this group, APS and AAPM recently conducted a qualitative survey on prescribing practices and attitudes. Over 470 physician members from the two organizations participated. These results will be shared with the work group at its next meeting on January 17. Watch for more information in next month’s APS E-News.

 

News Highlights from The Journal of Pain

The following highlights summarize selected articles from the December 2006 issue (volume 8, number 1).

Sex and Pain-Related Psychological Variables are Associated with Thermal Pain Sensitivity for Patients with Chronic Low Back Pain
Steven Z. George, Virgil T. Wittmer, Roger B. Fillingim, and Michael E. Robinson
University of Florida

There have been many published studies comparing and evaluating thermal pain sensitivity in healthy subjects, but not much research has been conducted on those with clinical pain syndromes. The authors studied 33 patients with low back pain to explore whether sex differences existed for thermal pain sensitivity and if sex, fear avoidance beliefs, and/or pain catastrophizing influenced thermal-pain sensitivity. This is known as the Fear-Avoidance Model of Exaggerated Pain Perception (FAMEPP).

The authors hypothesized that women with chronic low back pain would exhibit elevated pain sensitivity in response to evoked pain stimuli and that fear-avoidance beliefs and catastrophizing would significantly influence pain sensitivity for all subjects regardless of gender. The authors defined fear avoidance beliefs as comprising an individual’s pain experiences, present stress level, pain behavior, and personality traits. Catastrophizing was described as a general negative expectation that experienced pain will inevitably result in the worst possible outcome.

Based on self-report questionnaires of the study subjects, the authors concluded that sex differences were evident in this group because women showed lower pain tolerance. However, the survey results also indicated that fear avoidance beliefs were the only unique influence on first-pulse response to pain stimuli in both women and men. Therefore, fear avoidance was associated with immediate thermal-pain sensitivity.


Is High Fear of Pain Associated with Attentional Biases for
Pain-Related or General Threat?

Gordon J. G. Asmundson and Heather D. Hadjistravropoulos
University of Regina, Canada

The intent of this study was to review and clarify past mixed research findings related to establishing fear of pain as a critical variable stimulating hypervigilance and vulnerability to the disabling effects of pain. A previous study had found that fear of pain was associated with faster detection of weak electrical stimuli regardless of clinical status.

The researchers reviewed recently published dot-probe data from 36 patients with musculoskeletal pain and from 29 healthy subjects. They concluded that patients with high pain fear levels displayed hypervigilance for all word types presented during the dot-probe task compared to those with low fear levels. The high pain fear subjects were almost exclusively musculoskeletal pain patients.

It appears from the data that high pain fear is associated with a general hypervigilance for potentially threatening stimuli. Fear of pain, therefore, can be used to categorize people more or less vulnerable to the disabling effects of pain, as those with high fear are likely to selectively react to all potentially threatening stimuli in their environment.


Musculoskeletal Pain in Primary Health Care: Subgroups Based on Pain Intensity, Disablity, Self Efficacy, and Fear Avoidance Variables
Eva Denison, Pernilla Asenlof, Maria Sandborgh, and Per Lindberg
Department of Public Health and Caring Sciences, Uppsala University, Sweden

Persistent pain is commonly treated in the primary care setting and musculoskeletal pain is the most frequently reported type of pain. The purpose of this study was to identify and describe subgroup profiles of these patients based on self-reported pain intensity, disability, self efficacy, fear of movement, and catastrophizing.

The researchers evaluated self-report questionnaires given to two groups of 215 and 161 patients at the start of physical therapy. Three subgroups were identified in the first group and replicated in the second. They were labeled as “high self-efficacy and low fear avoidance,” “low self-efficacy and low fear avoidance” and “low self-efficacy and high fear avoidance.”

The authors stated that the high self-efficacy and low fear avoidance group was the largest subgroup in both samples, and therapeutic management of these patients could be based on a general fitness approach in which they would be expected to self-manage extensively. For those with a combination of high pain levels and disability and low self-efficacy, the authors recommended a treatment approach that would enhance self-efficacy beliefs regarding the performance of desired activities by focusing on mastery of required motor skills. For the third subgroup, characterized by high pain levels and disability and high fear avoidance, they advocated an approach that assesses what movements or activities elicit fear and to follow up with gradual activity increases to reduce catastrophizing and fear and to enhance self-efficacy.

 

Travel Support for the APS 26th Annual Scientific Meeting

APS will again offer Young Investigator Awards for travel to the 2007 meeting. Awards are available to individuals presenting paper or poster abstracts at the meeting, May 2–5, 2007, in Washington, DC. Applicants may be from any research training background (basic or clinical science, psychology, medicine, or biostatistics) and may be at any level in training, including students, residents, predoctoral trainees, postdoctoral fellows, or those who have completed their postdoctoral training within the last 3 years. All applicants must be members of APS.

Please consult with your institution to verify that you can accept a cash award from APS before submitting an application for Young Investigator funding. Some institutions have policies that only allow for in-kind contributions, and APS will distribute cash awards to those chosen to receive Young Investigator awards.

To apply for funding, complete the Young Investigator Travel Stipend Application located on the APS Web site (beginning January 15, 2007). Applications must be completed online by February 19, 2007. If you have difficulty completing the application, contact Jennifer Reinard at jreinard@connect2amc.com or 847/375-4833. Applications will be reviewed by the APS Scientific Program Planning Committee and stipends will be awarded by March 12, 2007. Notifications will be sent to all applicants after March 12. All eligible young investigators will receive their travel grants at the Annual Meeting.

The APS travel stipend program is made possible through external grants as well as an allocation of operating funds from the American Pain Society.

 

Centers of Excellence: Deadline Is Almost Here!


APS created the Centers of Excellence (COE) in Pain Management Awards Program to help advance the quality of pain management in the United States by recognizing and rewarding excellence in quality clinical care. Any multidisciplinary program that provides direct patient care and is primarily focused on the treatment of pain is eligible to apply. Applications will be accepted through January 19, 2007, and award recipients will be announced by the end of the first quarter of 2007. Applications must be submitted online.

 

Country Profiles on Opioid Availability Now Available

The Pain & Policy Studies Group (PPSG) recently announced enhancements to the international section of its Web site that may be useful for individuals and organizations interested in improving availability and access to essential opioid medications. The PPSG Web site now offers country profiles that provide standardized information about opioid availability and key policy-related indicators for every country in the world. Each country profile contains graphs that portray the trend in reported national consumption of principal opioids as an indicator of opioid availability. Key policy-related indicators are provided, including whether the country is a party to the international conventions that require governments to estimate their medical requirements for opioids and to report consumption statistics to the International Narcotics Control Board. Country profiles can be accessed directly at www.painpolicy.wisc.edu/internat/countryprofiles.htm or from the PPSG home page.

 

APS Bulletin Online

Past issues of the APS Bulletin are archived online for your convenience and reference. This month, we’re highlighting three articles that perhaps you may have missed when they were first published.

Overcoming Legal Barriers to Competent and Compassionate Pain Relief for Patients with Chronic Nonmalignant Pain
Ben Rich, MD JD
(Volume 15, Number 4, Fall 2005)

Veterans Health Administration National Pain Management Strategy: Update and Future Directions
Robert D. Kerns, John Booss, Martha Bryan, Michael E. Clark, Audrey C. Drake, Rollin M. Gallagher, Beverly Green-Rashad, Ruth Markham, Jack Rosenberg, Anne Turner
(Volume 16, Number 1, Winter 2006)

Practical Controlled Trials: Researching the Therapeutic Ritual and All Its Parts
David Rakel, MD
(Volume 16, Number 3, Fall 2006)